| Identification | More | [Name]
2-Aminothiazole | [CAS]
96-50-4 | [Synonyms]
1,3-THIAZOL-2-YLAMINE
2-AMINOTHAZOLE
2-AMINOTHIAZOL
2-AMINOTHIAZOLE
2-THIAZOLAMINE
2-THIAZOLYLAMINE
2-THIAZYLAMINE
2-THIOZOLYLAMINE
ABADOLE
AKOS 204-05
AKOS BBS-00004392
AURORA KA-677
AURORA KA-7822
BASEDOL
THIAZYLAMINE
1,3-Thiazol-2-amine
2-Amino-1,3-thiazole
4-Thiazolin-2-onimine
Abadol
aminothiazol | [EINECS(EC#)]
202-511-6 | [Molecular Formula]
C3H4N2S | [MDL Number]
MFCD00005325 | [Molecular Weight]
100.14 | [MOL File]
96-50-4.mol |
| Chemical Properties | Back Directory | [Appearance]
brown crystalline powder, grains, lumps or flakes | [Melting point ]
91-93 °C (lit.) | [Boiling point ]
117 °C (15.002 mmHg)
| [bulk density]
600kg/m3 | [density ]
1.241 (estimate) | [vapor pressure ]
<1 hPa (20 °C) | [refractive index ]
1.5300 (estimate) | [Fp ]
117°C/15mm | [storage temp. ]
Hormones | [solubility ]
1 M HCl: soluble50mg/mL, clear (dark yellow-brown) | [form ]
Crystalline Powder, Grains, Lumps or Flakes | [pka]
5.36(at 20℃) | [color ]
Brown | [PH]
9.6 (100g/l, H2O, 20℃) | [Water Solubility ]
100 g/L (20 ºC) | [Detection Methods]
GC,NMR | [Merck ]
14,479 | [BRN ]
105738 | [InChI]
1S/C3H4N2S/c4-3-5-1-2-6-3/h1-2H,(H2,4,5) | [InChIKey]
RAIPHJJURHTUIC-UHFFFAOYSA-N | [SMILES]
[s]1[c]([nH]cc1)=N | [LogP]
0.380 | [CAS DataBase Reference]
96-50-4(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Aminothiazole(96-50-4) | [Storage Precautions]
Store under nitrogen;Light sensitive | [EPA Substance Registry System]
96-50-4(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302 | [Precautionary statements ]
P301+P312+P330 | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36:Irritating to the eyes.
R36/37:Irritating to eyes and respiratory system .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S39:Wear eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
XJ2100000
| [F ]
8-9 | [Autoignition Temperature]
600 °C | [Hazard Note ]
Irritant | [TSCA ]
Yes | [REACH Registrations]
Active | [HS Code ]
29341000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral | [Toxicity]
LD50 orally in Rabbit: 480 mg/kg |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Thiourea-->Chloroacetaldehyde | [Preparation Products]
ethyl 2-(2-aminothiazol-5-ylthio)acetate-->BASIC RED 29-->2-Amino-5-nitrothiazole-->2-Amino-((1-carboxy-1-methyl ethoxy)imino)-4-thiazoleacetic acid-->3-(-Hydroxyphenethyl)-2-imino thiazolidine-->2-Amino-5-bromothiazole monohydrobromide-->2-Chloro-5-nitrothiazole-->1,3-Thiazole-2-carbaldehyde-->Cationic Violet 3BL-->2-Amino-5-bromothiazole-->Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid-->Nitazoxanide Impurity-->Oxazole-2-amine-->CHEMBRDG-BB 4024592-->4,5,6,7-tetrachloro-2-(1,3-thiazol-2-yl)isoindole-1,3-dione-->2,2,2-trichloro-N-1,3-thiazol-2-ylacetamide-->2-Pyridinamine, N-(5-bromo-2-thiazolyl)--->1H-Benz[de]isoquinoline-1,3(2H)-dione,2-(2-thiazolyl)- |
| Hazard Information | Back Directory | [General Description]
Light brown crystals or brown granular solid. | [Reactivity Profile]
2-AMINOTHIAZOLE(96-50-4) reacts violently when nitrated with nitric or nitric-sulfuric acids. 2-AMINOTHIAZOLE(96-50-4) is also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. | [Air & Water Reactions]
Insoluble in water. | [Fire Hazard]
Flash point data for this chemical are not available; however, 2-AMINOTHIAZOLE is probably combustible. | [Chemical Properties]
brown crystalline powder, grains, lumps or flakes | [Uses]
2-Aminothiazole is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds. | [Uses]
antithyroid agent | [Uses]
Usually used in the synthesis of 2-aminothiazole-modified silica gel，and aslo used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation. | [Definition]
ChEBI: A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 76, p. 693, 1954 DOI: 10.1021/ja01632a016 | [Biochem/physiol Actions]
2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders. | [Safety Profile]
Poison by ingestion andintraperitoneal routes. Mutation data reported.Spontaneous ignition occurs at 100°. Mixtures with nitricacid or nitric acid + sulfuric acid explode on heating.Incompatible with HNO3 and H2SO4. When heated todecomposition it emi | [Purification Methods]
It crystallises from pet ether (b 100-120o), or EtOH. [Beilstein 27 III/IV 4574.] |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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